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Although this shift brings Medicare closer to “breaking even” if GLP-1RAs are covered for weight management, a new analysis led by experts at the University of Chicago finds that the new policy isn’t quite there yet
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However, the first non-peptide ligand at GLP-1R was in fact an antagonist, T-0632, which competes with 125 I-Ex4(9-39) at hGLP-1R with an IC 50 of 1.2 µM and was able to antagonize GLP-1-induced cAMP production in COS-7 cells (Tibaduiza et al ., 2001)
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